Epidemiology and Genetic Risk Factors in the US
Osteosarcoma remains a rare disease, with approximately 1,000 new cases diagnosed in the United States each year.
About half of these cases occur in children and adolescents, typically between the ages of 10 and 30. While most cases are sporadic, US researchers in 2026 place heavy emphasis on genetic screening for hereditary syndromes. Patients with Li-Fraumeni syndrome (mutations in the TP53 gene), Retinoblastoma (RB1 gene mutations), or Rothmund-Thomson syndrome are at a significantly higher risk. Environmental factors, such as prior exposure to high-dose radiation therapy for other childhood cancers, also serve as a key risk factor monitored by US oncology clinics.
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